skip menus and go right to content

 SEARCH

 LifeWatch

LifeWatch Employee Assistance Program
1-800-333-6228
Or
TTT/TTY
1-800-745-5555


 RESOURCES


 MORE


 

HOME TOPICS NEWS READING ABOUT HELP
 
 
Schizophrenia - Dopamine Receptor Density May Affect Schizophrenia Risk
Topic Home  Related:  
Dopamine Receptor Density May Affect Schizophrenia Risk
(HealthDay News)
by -- Alka Agrawal
Updated: Oct 6th 2006

new article illustration

FRIDAY, Oct. 6 (HealthDay News) -- A study of twins has shown that a high density of dopamine D1 receptors increases the risk of schizophrenia, researchers report in the October issue of the American Journal of Psychiatry.

Jarmo Hietala, M.D., Ph.D., from the University of Turku in Finland, and colleagues examined D1 receptor binding in nine twin pairs discordant for schizophrenia (four monozygotic and five dizygotic), two additional unaffected co-twins and 13 healthy comparison twins, by positron emission tomography.

The researchers found that high D1 receptor binding in the medial prefrontal cortex, superior temporal gyrus and angular gyrus was associated with an increased risk of schizophrenia. There was also a widespread reduction in D1 receptor binding in medicated schizophrenia patients and a lower receptor binding in the frontotemporal regions in patients treated with high doses of anti-psychotic drugs.

"This study demonstrated an association between genetic risk for schizophrenia and alterations in cortical D1 receptor binding, an observation that has implications for future studies of the molecular genetics of schizophrenia," the authors conclude.

Abstract
Full Text (subscription or payment may be required)

 

 BASIC INFORMATION

 DETAILED INFORMATION

 NEWS

 LINKS

 BOOK REVIEWS